Search results for " DDHD1"
showing 2 items of 2 documents
Oligonucleotidi complementari a DDH1 e loro uso per la prevenzione e il trattamento dei tumori”
2017
La presente invenzione si riferisce al settore delle biotecnologie e della farmaceutica poiché fornisce degli oligonucleotidi complementari alla sequenza di DDH1 o parti di essa, che possono essere facoltativamente veicolati da vettori lipidici, i quali sono in grado di inibire la proliferazione e indurre la morte cellulare di cellule tumorali e pertanto possono essere impiegati per la prevenzione e la cura dei tumori.
The phospholipase DDHD1 as a new target in colorectal cancer therapy
2018
Background Our previous study demonstrates that Citrus-limon derived nanovesicles are able to decrease colon cancer cell viability, and that this effect is associated with the downregulation of the intracellular phospholipase DDHD domain-containing protein 1 (DDHD1). While few studies are currently available on the contribution of DDHD1 in neurological disorders, there is no information on its role in cancer. This study investigates the role of DDHD1 in colon cancer. Methods DDHD1 siRNAs and an overexpression vector were transfected into colorectal cancer and normal cells to downregulate or upregulate DDHD1 expression. In vitro and in vivo assays were performed to investigate the functional…